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With the idea that a more fast cell cycle is really a vital element of pluripotency, reprogramming efficiency can be improved. Methods for bettering pluripotency via manipulation of cell cycle regulators include: overexpression of Cyclin D/Cdk4, phosphorylation of Sox2 at S39 and S253, overexpression of Cyclin A and Cyclin E, knockdown of Rb, and k

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